Sophomore Seminars

Lymphocyte Migration


To participate in immune surveillance and the development of inflammation, lymphocytes must exit the blood stream and enter tissues. This process, known as lymphocyte migration, involves a complex series of adhesion, activation, and diapedesis events. We will discuss the cellular mechanisms that are involved in lymphocyte migration. The major players include (1) lymphocyte adhesion molecules that interact with their counter-receptors on blood vessel endothelia cells, and (2) a variety of molecules, including cytokines and chemokines, which attract or activate lymphocytes. The role of these molecules in the development of human diseases such as asthma, Type 1 diabetes, and multiple sclerosis will be emphasized.

Meet the Instructor(s)

Sara Michie

"I'm a professor in the Pathology Department at the School of Medicine, and split my work time between performing autopsies and teaching immunology and pathology to medical students and graduate students. I've taught this IntroSem for over 20 years and have had amazing students every year. In my leisure time, I enjoy sports and outdoor activities, including surfing, basketball, backpacking, playing fetch with my yellow lab, and rooting for the Stanford lacrosse team. Most importantly, I'm 100 percent Texan, and proud of it."