Sophomore Seminars

Lymphocyte Migration


To participate in immune surveillance and the development of inflammation, lymphocytes must exit the blood stream and enter tissues. This process, known as lymphocyte migration, involves a complex series of adhesion, activation, and diapedesis events. We will discuss the cellular mechanisms that are involved in lymphocyte migration. The major players include (1) lymphocyte adhesion molecules that interact with their counter-receptors on blood vessel endothelia cells, and (2) a variety of molecules, including cytokines and chemokines, which attract or activate lymphocytes. The role of these molecules in the development of human diseases such as asthma, Type 1 diabetes, and multiple sclerosis will be emphasized.

Meet the Instructor(s)

Sara Michie

"I'm a professor in the Pathology Department at the School of Medicine, and split my work time between teaching, autopsy pathology, and immunology research. I've taught this IntroSem for about 20 years. It's by far the most fun I've had at Stanford. I especially enjoy interacting with students outside of the classroom. In my leisure time, I enjoy sports and outdoor activities, including surfing, basketball, and backpacking. Most importantly, I'm 100 percent Texan, and proud of it."