Look for the catalog of 2020-21IntroSems to roll out here in August.
To participate in immune surveillance and the development of inflammation, lymphocytes must exit the blood stream and enter tissues. This process, known as lymphocyte migration, involves a complex series of adhesion, activation, and diapedesis events. We will discuss the cellular mechanisms that are involved in lymphocyte migration. The major players include (1) lymphocyte adhesion molecules that interact with their counter-receptors on blood vessel endothelia cells, and (2) a variety of molecules, including cytokines and chemokines, which attract or activate lymphocytes. The role of these molecules in the development of human diseases such as asthma, Type 1 diabetes, and multiple sclerosis will be emphasized.